John Cacioppo is the Tiffany and Margaret Blake Distinguished Service Professor and the founder and director of the Center for Cognitive and Social Neuroscience at the University of Chicago. He is also the founding faculty director of the Arete Initiative of the Office of the Vice President for Research and National Laboratories at the University of Chicago.

John is one of the founders of the field of social neuroscience and the author of more than 500 scientific articles, chapters, reviews, and commentaries, and he has authored or edited more than 20 books. His research has been funded continuously since 1978 through federal grants from the National Science Foundation and the National Institutes of Health. He served on the faculty of the University of Notre Dame (1977–1979), University of Iowa (1979–1989), and Ohio State University (1989–1999) prior to joining the faculty at the University of Chicago. He has also served as an external professor chair in Social Neurosciences at Free University Amsterdam in the Netherlands and is a guest professor at the State Key Laboratory of Cognitive Neuroscience and Learning at Beijing Normal University in China.

John has served on various journal boards as well, and is a past editor of Psychophysiology and a former associate editor of Psychological ReviewPerspectives on Psychological Science, and Social Neuroscience